Mucosal Viruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:A Missing Piece of the Puzzle?

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Perera, Krishani Dinali, Cameron, Paige, Sarwar, Tayyibah and Carding, Simon R. (2025) Mucosal Viruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:A Missing Piece of the Puzzle? International Journal of Molecular Sciences, 26 (22). pp. 1-20. ISSN 1661-6596

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Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition without a definitive aetiology, no reliable diagnostic test, and no proven effective treatment. Despite most patients reporting a post-viral onset of illness, findings to date are conflicting on whether a single virus or multiple viral triggers are involved. Most studies to date have focused on detecting viruses in blood and circulating immune cells with relatively few investigating the presence of viruses in mucosal sites. In this review, we propose that this represents a critical gap in understanding the pathophysiology of ME/CFS knowledge, as mucosal tissues are primary entry points for most pathogens and often serve as reservoirs where viruses may persist. Consequently, they represent ideal niches for identifying persistent infections in ME/CFS. Emerging evidence from saliva and other mucosal samples in ME/CFS patients is consistent with this proposal and that latent viruses can persist and periodically reactivate in mucosal tissues from where they can potentially contribute to immune dysregulation, chronic inflammation, and increased symptom severity that defines ME/CFS.

Item Type: Article
Uncontrolled Keywords: dna viruses,mucosal reservoirs,cfs),rna viruses,viral persistence,catalysis,molecular biology,computer science applications,spectroscopy,physical and theoretical chemistry,organic chemistry,inorganic chemistry ,/dk/atira/pure/subjectarea/asjc/1500/1503
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 19 May 2026 14:21
Last Modified: 19 May 2026 14:21
URI: https://ueaeprints.uea.ac.uk/id/eprint/103109
DOI: 10.3390/ijms262211161

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