The amygdala volume moderates the relationship between childhood maltreatment and callous-unemotional traits in adolescents with conduct disorder

Jiang, Yali, Gao, Yidian, Dong, Daifeng, Sun, Xiaoqiang, Situ, Weijun and Yao, Shuqiao (2025) The amygdala volume moderates the relationship between childhood maltreatment and callous-unemotional traits in adolescents with conduct disorder. European Child and Adolescent Psychiatry, 34 (1). pp. 205-214. ISSN 1018-8827

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Abstract

CU traits, characterized by shallow affect, lack of fear, and absence of remorse, have been moderately associated with childhood maltreatment in a recent meta-analysis. However, the potential impact of brain structures remains undetermined. This paper examines the relationship between callous-unemotional (CU) traits, childhood maltreatment, and amygdala volumes. In this study, we used a region-of-interest (ROI) analysis to explore the interaction between the volumes of the amygdala, childhood maltreatment, and the manifestation of CU traits in adolescents diagnosed with conduct disorder (CD, N = 67), along with a comparison group of healthy-control youths (HCs, N = 89). The ROI analysis revealed no significant group differences in the bilateral amygdalar volumes. Significant positive correlation was discovered between all forms of child maltreatment (except for physical neglect) and CU traits across subjects. But the interaction of physical abuse and amygdala volumes was only significant within CD patients. Notably, a sensitivity analysis suggested that gender significantly influences these findings. These results contribute critical insights into the etiology of CU traits, emphasizing the need for customized clinical assessment tools and intervention strategies.

Item Type:	Article
Uncontrolled Keywords:	amygdala,callous-unemotional traits,childhood maltreatment,conduct disorder,pediatrics, perinatology, and child health,developmental and educational psychology,psychiatry and mental health,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2735
Faculty \ School:	Faculty of Social Sciences > School of Psychology
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	18 May 2026 11:53
Last Modified:	18 May 2026 11:53
URI:	https://ueaeprints.uea.ac.uk/id/eprint/103069
DOI:	10.1007/s00787-024-02482-y

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