Tools
ToolsFabbrizi, Emanuele, Hailu, Gebremedhin Solomon, Ganesan, A., Fioravanti, Rossella, Zwergel, Clemens, Lambona, Chiara, Valente, Sergio, Fianco, Giulia, Iuzzolino, Angela, Trisciuoglio, Daniela, Caroli, Jonatan, Mattevi, Andrea, Häberli, Cécile, Keiser, Jennifer, Rotili, Dante and Mai, Antonello (2025) Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni. ACS Infectious Diseases, 11 (8). pp. 2178-2189. ISSN 2373-8227
Preview |
PDF (tranylcypromine-based-lsd1-inhibitors-as-useful-agents-to-reduce-viability-of-schistosoma-mansoni)
- Published Version
Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cytotoxicity,lsd1,lysine demethylases,reduction of viability,s. mansoni,infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2725 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 May 2026 10:32 |
| Last Modified: | 18 May 2026 10:32 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103064 |
| DOI: | 10.1021/acsinfecdis.5c00224 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |