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ToolsSobhan, Rashed, Thrippleton, Michael J., Willis, David R., Gillings, Rachel, Sami, Saber, Wardlaw, Joanna M., Minihane, Anne-Marie, Berry, Narelle M. and Cameron, Donnie (2026) Subtle blood-brain barrier leakage quantification using DCE-MRI in subjective and mild cognitive impairment: A pilot sub-study of the Cognitive Ageing, Nutrition & Neurogenesis (CANN) trial. Heliyon, 12 (3). ISSN 2405-8440
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Abstract
The pathophysiology of dementia relates to leakage of the aging blood-brain barrier (BBB). Dynamic contrast-enhanced (DCE)-MRI quantifies this leakage and may facilitate early diagnosis and treatment monitoring. Here, we present preliminary work comparing BBB leakage and T1 between mild and subjective cognitive impairment (MCI and SCI) participants (n = 6 and 17, respectively) after year-long consumption of a combined omega-3 fatty acid (fish oil capsules) and cocoa flavanol-3-ol (chocolate drops) dietary supplement or matched-control (n = 1/5 MCI and 9/8 SCI). DCE-MRI data from white matter, grey matter, hippocampus, thalamus, and amygdala were fitted with the Patlak model to obtain the permeability-surface-area product (PS), and pre-contrast T1 was calculated. No differences were observed between intervention groups. After combining control and active groups, we observed greater leakage (PS) in the MCI hippocampus (p = 0.019) and thalamus (p = 0.042) versus SCI, and longer T1 values in MCI white matter (p = 0.042) and thalamus (p = 0.023). This preliminary study indicates the potential utility of BBB leakage and T1 in differentiating MCI and SCI. This should be investigated further in larger trials.
| Item Type: | Article |
|---|---|
| Additional Information: | Availability of data and materials: The data that support the findings of this study are available from the corresponding author upon reasonable request. |
| Uncontrolled Keywords: | blood-brain barrier,dietary supplement,mild cognitive impairment,permeability,subjective memory impairment,t mapping,general ,/dk/atira/pure/subjectarea/asjc/1000 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 14 May 2026 15:16 |
| Last Modified: | 14 May 2026 15:16 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/103031 |
| DOI: | 10.1016/j.heliyon.2026.e44621 |
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