Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

Razieh, Azaria C., Sample, Harry C., Hobson, Emily B., Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434, Prior, Timothy J. and Redshaw, Carl ORCID: https://orcid.org/0000-0002-2090-1688 (2026) Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone. Chemical communications (Cambridge, England). ISSN 1359-7345

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Abstract

From reactions of M(OAc)2·nH2O (M = Cu, Mn) or Cu(NO3)2·3H2O with p-methyl-N,N’-dimethyldiazacalix[4]areneH4 (p-MeLH4) under aerobic conditions, rare examples of azacalixarene-3d-metal complexes were isolated. These, thermally stable non-toxic compounds (≤ µM IC50 values) were screened as catalysts for the ring opening polymerization of the cyclic esters ε-caprolactone (ε-CL) and δ-valerolactone (δ-VL) affording low molecular weight cyclic or linear (H/OH end group) polymers. The Mn-based system exhibited the higher activity.

Item Type:	Article
Uncontrolled Keywords:	3* ,/dk/atira/pure/researchoutput/REFrank/3_
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
UEA Research Groups:	Faculty of Science > Research Groups > Pharmacology and Biological Chemistry
Depositing User:	LivePure Connector
Date Deposited:	12 May 2026 16:36
Last Modified:	24 Jul 2026 08:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102975
DOI:	10.1039/d6cc00888g

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