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ToolsAl-Khalasi, Usama Said Shannan, Al-Sarrai Al-Alalawi, Awatif Khamis Said, Al-Jufaili, Mahmood, Al-Reesi, Abdullah, Al-Zakwani, Ibrahim, Al-Asmi, Muzna Said Rashid, Al-Riyami, Fatma Bader and Vishwakarma, Ramesh (2024) Atomized Intranasal Ketorolac Versus Intravenous Ketorolac for the Treatment of Severe Renal Colic in the Emergency Department: A Double-Blind, Randomized Controlled Trial. Annals of Emergency Medicine, 83 (3). pp. 217-224. ISSN 0196-0644
Full text not available from this repository. (Request a copy)Abstract
Study objective: Atomized intranasal (IN) drug administration offers an alternative to the intravenous (IV) route. We aimed to evaluate the analgesic efficacy of IN versus IV ketorolac in emergency department patients with acute renal colic. Methods: We conducted a double-blind, randomized controlled trial on adult patients (aged 18 to 64 years) with severe renal colic and numerical rating scale pain ratings ≥7.0. They were randomly assigned (1:1) to receive single doses of either IN or IV ketorolac. Our main outcomes were differences in numerical rating scale reduction at 30 and 60 minutes. A 95% confidence interval (CI) was calculated for each mean difference, with a minimum clinically important difference set at 1.3 points. Secondary outcomes included treatment response, adverse events, rescue medications, and emergency department revisits. We analyzed using intention-to-treat. Results: A total of 86 and 85 patients with similar baseline characteristics were allocated to the IV and IN groups, respectively. Mean numerical rating scale scores were 8.52 and 8.65 at baseline, 3.85 and 4.67 at 30 minutes, and 2.80 and 3.04 at 90 minutes, respectively. The mean numerical rating scale reduction differences between the IV and IN groups were 0.69 (95% CI -0.08 to 1.48) at 30 minutes and 0.10 (95% CI -0.85 to 1.04) at 60 minutes. There were no differences in secondary outcomes. Conclusion: Neither IN or IV ketorolac was superior to the other for the treatment of acute renal colic, and both provided clinically meaningful reductions in pain scores at 30 to 60 minutes.
| Item Type: | Article |
|---|---|
| Additional Information: | We comply with the journal’s data sharing policy by providing access to the deidentified participant data used in our randomized controlled trial upon request. To obtain the dataset, a comprehensive data dictionary, and the analytic code used for data analysis, please contact Al-khalasi, MD, via email at u.alkhalasi@gmail.com |
| Uncontrolled Keywords: | emergency medicine ,/dk/atira/pure/subjectarea/asjc/2700/2711 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Public Health Faculty of Medicine and Health Sciences > Research Centres > Population Health (former - to 2025) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Apr 2026 13:34 |
| Last Modified: | 14 Apr 2026 13:34 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102774 |
| DOI: | 10.1016/j.annemergmed.2023.10.009 |
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