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Merinopoulos, Ioannis, Corballis, Natasha, Bhalraam, U., Natarajan, Rajkumar 
ORCID: https://orcid.org/0000-0001-8636-8452, Gunawardena, Tharusha, Reinhold, Johannes ORCID: https://orcid.org/0000-0003-2412-2574, Maart, Clint, Sawh, Chris, Sulfi, Sreekumar, Wistow, Trevor, Ryding, Alisdair, Gilbert, Tim, Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752 and Eccleshall, Simon C.
(2026)
Assessment of Paclitaxel Drug-Coated Balloon-Only Angioplasty for Multivessel Coronary Artery Disease.
Journal of Clinical Medicine, 15 (1).
ISSN 2077-0383
Abstract
Background: There are limited data about the use of drug-coated balloon (DCB)-only angioplasty for multivessel coronary disease. Objectives: The aim of this study was to assess the safety and efficacy of DCB-only angioplasty as compared with second-generation drug-eluting stents (DESs) in patients undergoing multivessel angioplasty. Methods: We compared major adverse cardiovascular events (MACEs) in all patients undergoing multivessel angioplasty in our institution from 1 January 2015 until 15 November 2019, with either the DCB-only or DES-only strategy. The primary endpoint of our study was a MACE, including cardiovascular mortality, acute coronary syndrome, target lesion revascularisation, stroke, or major bleeding. Data were analysed using Cox regression models, Kaplan–Meier estimator plots, and propensity score matching. Results: A total of 159 consecutive patients treated with DCB-only angioplasty and 222 consecutive patients treated with DES-only angioplasty were identified. The majority of the vessels treated were large vessels (>3 mm). After a median follow-up of 4 years, a total of 52 (33%) patients in the DCB and 73 (33%) patients in the DES group encountered a MACE (p = 0.97). The results did not change following propensity score matching. On multivariate Cox regression analysis in the propensity score-matched cohort, atrial fibrillation [HR = 2.37, CI: (1.22–4.61), p = 0.011] and diabetes [HR = 1.71, CI: (1.13–2.60), p = 0.011] were the only independent adverse predictors of MACE. Conclusions: DCB-only angioplasty appears to be safe and efficient when compared to DES for multivessel angioplasty in terms of MACEs after a follow-up of 4 years.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: Data can be made available following appropriate request to the corresponding author. |
| Uncontrolled Keywords: | drug coated balloon only angioplasty,drug eluting stent,multivessel angioplasty,general medicine,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Mar 2026 16:30 |
| Last Modified: | 18 Jun 2026 20:54 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102156 |
| DOI: | 10.3390/jcm15010204 |
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