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Chen, Xuyang, de Seymour, Jamie V., Han, Ting Li, Xia, Yinyin, Chen, Chang, Zhang, Ting, Zhang, Hua and Baker, Philip N. 
ORCID: https://orcid.org/0000-0002-4592-6427
(2018)
Metabolomic biomarkers and novel dietary factors associated with gestational diabetes in China.
Metabolomics, 14 (11).
pp. 1-11.
ISSN 1573-3882
Abstract
Introduction: Gestational diabetes mellitus (GDM) is impaired glucose tolerance first recognised during pregnancy; its development is associated with many adverse outcomes. Mechanisms of GDM development are not fully elucidated and few studies have used Chinese participants. Objectives: The aim of this study was to investigate the maternal metabolome associated with GDM in a Chinese population, and explore the relationship with maternal diet. Methods: Ninety-three participants were recruited at 26–28 weeks’ gestation from Chongqing, China. Maternal urine, serum, and hair metabolomes were analysed using gas and liquid chromatography–mass spectrometry. Dietary intake was assessed using a 96-item food frequency questionnaire. Results: Of the 1064 metabolites identified, 73 were significantly different between cases and controls (P < 0.05), but only 2-aminobutyric acid had both a p- and q-value < 0.05. A “snack-based-dietary-pattern” was associated with an increased likelihood of GDM (odds ratio 2·1; 95% confidence interval 1.1–3.9). The association remained significant after adjustment for calorie intake but not food volume. Conclusion: This study provides a comprehensive characterization of the maternal metabolome. The snack-based dietary pattern associated with GDM suggests that timing and frequency of consumption are important factors in the relationship between maternal diet and GDM.
| Item Type: | Article |
|---|---|
| Additional Information: | We acknowledge the LC–MS scientific support provided by Dr. Kai Law. We also thank Xun Mao and Diqi Zhao for the help of data and sample collection. |
| Uncontrolled Keywords: | biomarker,gestational diabetes,maternal diet,metabolomics,endocrinology, diabetes and metabolism,biochemistry,clinical biochemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2712 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 27 Jan 2026 12:30 |
| Last Modified: | 18 Jun 2026 20:51 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/101744 |
| DOI: | 10.1007/s11306-018-1445-6 |
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