The molecular biology of scrapie:the last two years

Hope, James ORCID: https://orcid.org/0000-0003-2015-2389 and Kimberlin, Richard H. (1987) The molecular biology of scrapie:the last two years. Trends in Neurosciences, 10 (4). pp. 149-164. ISSN 0166-2236

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Abstract

Galanin and/or GAL-like peptide(s) are distributed throughout the body in most mammalian species. Their physiological function and/or pathophysiological importance remain to be elucidated. The production and secretion of a pre-galanin message peptide and a galanin message-associated peptide (GMAP), or a fragment thereof, has yet to be established, and the regulation of the GAL message remains to be studied. Functional as well as immunohistochemical data so far suggest that a GAL-like peptide may be involved in the local regulation of pancreatic endocrine function, gastro-intestinal motility, growth hormone and prolaction release, feeding behavior and primary sensory input. The detailed mapping of GAL-LI in several mammalian species to date hints at the many biological actions of this newly discovered, widely distributed neuropeptide, and allows studies of GAL function to be planned.

Item Type:	Article
Uncontrolled Keywords:	general neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2800
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	08 Dec 2025 16:30
Last Modified:	18 Jun 2026 20:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101341
DOI:	10.1016/0166-2236(87)90041-5

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