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Chung, Yuen Li, Williams, Alun, Chong, Angela, Hope, James 
ORCID: https://orcid.org/0000-0003-2015-2389, Williams, Steve C.R. and Bell, Jimmy D.
(1996)
Metabolic changes associated with vacuolation in murine models of scrapie using in vitro 1H-NMR spectroscopy.
NMR in Biomedicine, 9 (8).
pp. 359-363.
ISSN 0952-3480
Abstract
In this study, metabolic changes in the 79A/C3H, ME7/VM, ME7/C3H, 87V/VM and 22A/SV scrapie mouse models were investigated during the clinical phase of the disease, using in vitro proton nuclear magnetic resonance spectroscopy. N-acetyl-aspartate was found to be significantly reduced in infected mice of the ME7/C3H (40% reduction), ME7/VM (26%) and 79A/C3H (17%) models when compared to control mice, but not in the 87V/VM and 22A/SV models. The concentration of choline containing compounds and creatine remain unchanged in all models when compared with control murine brains. The level of N-acetyl-aspartate reduction correlated with the extent of grey-matter brain vacuolation. The levels of myo-inositol were found to be significantly increased in the ME7/VM (143%) and 79A/C3H (132%) models only and no significant changes were observed in the ME7/C3H, 87V/VM and 22A/SV models. These changes did not correspond to the severity of gliosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | gliosis,in vitro,mouse model,myo-inositol,n-acetyl asparate,neurodegeneration,proton nuclear magnetic resonance spectroscopy,scrapie,vacuolation,molecular medicine,radiology nuclear medicine and imaging,spectroscopy ,/dk/atira/pure/subjectarea/asjc/1300/1313 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 08 Dec 2025 16:30 |
| Last Modified: | 18 Jun 2026 20:49 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/101327 |
| DOI: | 10.1002/(SICI)1099-1492(199612)9:8<359::AID-NBM428>3.0.CO;2-D |
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