The association of a codon 136 PrP gene variant with the occurrence of natural scrapie

Hunter, N., Goldmann, W., Smith, G. and Hope, J. ORCID: https://orcid.org/0000-0003-2015-2389 (1994) The association of a codon 136 PrP gene variant with the occurrence of natural scrapie. Archives of Virology, 137 (1-2). pp. 171-177. ISSN 0304-8608

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Abstract

Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/ control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Bleu du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of sheep). However Val136 does not correlate with incidence of scrapie in two other flocks - Poll Dorsets and Suffolks - and there may therefore be breed differences in PrP genotypes affected by scrapie.

Item Type:	Article
Uncontrolled Keywords:	virology ,/dk/atira/pure/subjectarea/asjc/2400/2406
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	02 Dec 2025 15:30
Last Modified:	18 Jun 2026 20:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/101183
DOI:	10.1007/BF01311184

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