Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes

Swart, Maarten and Troeberg, Linda (2019) Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes. Journal of Histochemistry and Cytochemistry, 67 (1). pp. 9-27. ISSN 0022-1554

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    Abstract

    Heparan sulfate (HS) proteoglycans on immune cells have the ability to bind to and regulate the bioactivity more than 400 bioactive protein ligands, including many chemokines, cytokines, and growth factors. This makes them important regulators of the phenotype and behavior of immune cells. Here we review how HS biosynthesis in macrophages is regulated during polarization and in chronic inflammatory diseases such as rheumatoid arthritis, atherosclerosis, asthma, chronic obstructive pulmonary disease and obesity, by analyzing published micro-array data and mechanistic studies in this area. We describe that macrophage expression of many HS biosynthesis and core proteins is strongly regulated by macrophage polarization, and that these expression patterns are recapitulated in chronic inflammation. Such changes in HS biosynthetic enzyme expression are likely to have a significant impact on the phenotype of macrophages in chronic inflammatory diseases by altering their interactions with chemokines, cytokines, and growth factors.

    Item Type: Article
    Uncontrolled Keywords: heparan sulfate,inflammation,macrophages,proteoglycans,rheumatoid arthritis
    Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
    Related URLs:
    Depositing User: LivePure Connector
    Date Deposited: 07 Jan 2019 12:30
    Last Modified: 09 Jan 2019 01:11
    URI: https://ueaeprints.uea.ac.uk/id/eprint/69457
    DOI: 10.1369/0022155418798770

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