In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery

Bisharat, Lorina, Barker, Susan A., Narbad, Arjan and Craig, Duncan Q.M. (2019) In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery. International Journal of Pharmaceutics, 556. pp. 311-319. ISSN 0378-5173

[img] PDF (Accepted manuscript) - Submitted Version
Restricted to Repository staff only until 15 December 2019.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (691kB) | Request a copy

    Abstract

    This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of a digestible starch component within the inert zein would allow the film to remain intact until the large intestine is reached. Free films of zein alone and starch/zein were prepared and characterised. SEM and AFM images of film surface showed that films were morphologically inhomogeneous, particularly at lower HAS/Zein ratios; however, nanothermal analysis data suggested that these differences in appearance within the same film are not compositional differences, i.e. the systems are not phase-separated. Moreover, FT-IR could detect no molecular interaction between the two polymers. Paracetamol tablets were coated with HAS/Zein aqueous based coatings of different compositions to a TWG of 20%. Drug release from zein alone and 1:5 HAS/Zein coated tablets under upper gastrointestinal conditions (pH 1.2, pH 6.8 with pepsin and pancreatin included) was very similar (for example approximately 12% and 14% of the drug was released, respectively, after 6 hours in a sequential in vitro test), suggesting that release in this region is limited and is not influenced by the presence of HAS in the ratio to zein under study. Studies using an in vitro colon model showed that under simulated colonic conditions, the drug release was significantly (p < 0.05) more rapid from 1:5 HAS/Zein, compared to the zein alone coating formulation. These data therefore support the potential use of zein-starch mixed films for colonic targeting purposes.

    Item Type: Article
    Uncontrolled Keywords: zein,amylose,starch,colonic,drug delivery,fermentation studies
    Faculty \ School: Faculty of Science > School of Pharmacy
    Faculty of Science > School of Biological Sciences
    Related URLs:
    Depositing User: LivePure Connector
    Date Deposited: 19 Dec 2018 10:30
    Last Modified: 10 Feb 2019 04:30
    URI: https://ueaeprints.uea.ac.uk/id/eprint/69360
    DOI: 10.1016/j.ijpharm.2018.12.021

    Actions (login required)

    View Item