A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

Hemming, Ryan A., Bell, Megan, Duffy, Liam J., Bristow, Jonathan, Wallis, John D., Allin, Steven M. and Bulman Page, Philip C. (2019) A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets. Tetrahedron, 75 (1). pp. 121-127. ISSN 0040-4020

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    Abstract

    A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%.

    Item Type: Article
    Faculty \ School: Faculty of Science > School of Chemistry
    Depositing User: LivePure Connector
    Date Deposited: 27 Nov 2018 10:30
    Last Modified: 09 Apr 2019 13:56
    URI: https://ueaeprints.uea.ac.uk/id/eprint/69046
    DOI: 10.1016/j.tet.2018.11.050

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