Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma

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Gargiulo, M., Serra Mestre, J.M., Cortese, A., Murphy, D.C., Parascandolo, S. and Razzano, S. (2018) Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma. Journal of Cranio-Maxillofacial Surgery, 46 (11). pp. 1968-1974. ISSN 1010-5182

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Abstract

Purpose: Electrochemotherapy (ECT) is a therapeutic approach based on the local application of electrical pulses that permeabilize cell membranes to enhance the uptake of low-permeant chemotherapeutic agents, thus increasing their cytotoxic effects. Materials and Methods: Twenty-one patients with SCC of the lower lip were treated according to the European Standard Operating Procedures of Electrochemotherapy. Bleomycin (15,000 IU/m2 body surface area) was administered intravenously over a 1-minute period. Eight electrical pulses (amplitude, 1000 V/cm; duration, 100 μs) were generated and delivered at a repetition frequency of 5 kHz. Changes in tumor volume were used to assess treatment response. Results: Objective response (OR), complete response (CR), and partial response (PR) rates of 100%, 71.4%, and 28.6% respectively were demonstrated following a single session of ECT. ECT was well tolerated, and no adverse events occurred. Conclusions: Intravenous bleomycin-based ECT is a safe and effective therapy for SCC of the lower lip. ECT improves the quality-of-life of patients by preserving the function and the aesthetic appearance of the affected area. ECT provides a therapeutic option for elderly and frail patients who, due to their state of health, are not suitable for, or refuse surgical interventions.

Item Type: Article
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Depositing User: LivePure Connector
Date Deposited: 04 Sep 2018 09:32
Last Modified: 22 Oct 2022 04:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/68190
DOI: 10.1016/j.jcms.2018.08.013

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