New pathogenic paradigms in inflammatory bowel disease

Di Sabatino, Antonio, Biancheri, Paolo, Rovedatti, Laura, MacDonald, Thomas T and Corazza, Gino R (2012) New pathogenic paradigms in inflammatory bowel disease. Inflammatory Bowel Diseases, 18 (2). pp. 368-371. ISSN 1078-0998

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Abstract

Recent progresses in basic science have opened new pathogenic scenarios in inflammatory bowel disease. The T helper cell type (Th)1/Th2 paradigm has been outdated thanks to the advances in understanding the function of Th17 cells. Innate immunity, nonimmune cells, and defective tolerogenic mechanisms play a no less crucial role than do adaptive immunity, immune cells, and hyperactivation of effector mechanisms. These new paradigms, together with the no longer "static" but "dynamic" vision of intestinal inflammation, highlight new possible therapeutic targets in inflammatory bowel disease.

Item Type: Article
Additional Information: Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
Uncontrolled Keywords: adaptive immunity,humans,immune tolerance,immunity, innate,immunity, mucosal,immunology,immunology,immunology,immunology,immunology,immunology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: LivePure Connector
Date Deposited: 07 Aug 2018 17:30
Last Modified: 07 Aug 2018 20:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/67990
DOI: 10.1002/ibd.21735

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