Recent advances in understanding ulcerative colitis

Di Sabatino, Antonio, Biancheri, Paolo, Rovedatti, Laura, Macdonald, Thomas Thornton and Corazza, Gino Roberto (2012) Recent advances in understanding ulcerative colitis. Internal and Emergency Medicine, 7 (2). pp. 103-111. ISSN 1828-0447

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Abstract

Ulcerative colitis, one of the two main forms of inflammatory bowel disease, is characterized by inflammation of the large bowel with constant involvement of the rectum, and a possible continuous retrograde distribution up to the cecum. Typical macroscopic lesions are mucosal ulcerations, with immune cell infiltration and cryptic abscesses at histology. Ulcerative colitis usually manifests with bloody diarrhea, is associated with a number of extra-intestinal manifestations, and may be acutely complicated by toxic megacolon. Longstanding disease may predispose to the development of colorectal cancer. Therapeutic options include mesalazine, corticosteroids, immunomodulators and biologic agents; however, if these treatments fail, the only available therapeutic choice remaining is the surgical removal of the colon. This review emphasizes novel concepts in the basic aspects of ulcerative colitis, and, in addition to the current clinical and diagnostic knowledge, it also describes new treatment options for this condition.

Item Type: Article
Uncontrolled Keywords: biopsy, needle,methods,mortality,epidemiology,combined modality therapy,disease progression,female,humans,immunohistochemistry,pathology,male,epidemiology,therapeutic use,pathology,prognosis,recurrence,risk assessment,severity of illness index,survival rate
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: LivePure Connector
Date Deposited: 07 Aug 2018 17:30
Last Modified: 08 Aug 2018 11:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/67986
DOI: 10.1007/s11739-011-0719-z

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