Proteases and small intestinal barrier function in health and disease

Giuffrida, Paolo, Biancheri, Paolo and MacDonald, Thomas T (2014) Proteases and small intestinal barrier function in health and disease. Current Opinion in Gastroenterology, 30 (2). pp. 147-153. ISSN 0267-1379

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Abstract

PURPOSE OF REVIEW: To summarize the recent knowledge regarding intestinal proteases and the gut barrier. RECENT FINDINGS: It is now well established that intestinal proteases, such as matrix metalloproteinase (MMP)-1, MMP-3, MMP-10 and MMP-12, are key players in the development of ulcers in inflammatory bowel disease, have direct effects on epithelial barrier function and are involved in epithelial restitution. However, more recent work has suggested that the membrane-anchored epithelial cell serine protease matriptase is critical in maintaining the gut barrier, and roles have also been described for elastase, MMP-13, gelatinases, mast cell proteases and proteases derived from parasites and gut bacteria. Interestingly, epithelial proteases often co-localize with epithelial adherens junctions, and nonepithelial-derived proteases have junctional proteins as targets. SUMMARY: The role of proteases in controlling normal barrier function in the gut is now becoming very clear, to go alongside their role in intestinal inflammation.

Item Type: Article
Uncontrolled Keywords: enzymology,humans,enzymology,physiology,enzymology,enzymology,enzymology,physiology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: LivePure Connector
Date Deposited: 07 Aug 2018 17:30
Last Modified: 07 Aug 2018 20:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/67976
DOI: 10.1097/MOG.0000000000000042

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