Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease

Di Sabatino, Antonio, Miceli, Emanuela, Dhaliwal, Winnie, Biancheri, Paolo, Salerno, Raffaele, Cantoro, Laura, Vanoli, Alessandro, De Vincenzi, Massimo, Blanco, Camillo Del Vecchio, MacDonald, Thomas T and Corazza, Gino R (2008) Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease. American Journal of Clinical Pathology, 130 (1). pp. 34-42. ISSN 1943-7722

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Abstract

Paneth cells, granulated epithelial cells located at the base of small bowel crypts, have a crucial role in innate immunity. Because controversies remain concerning Paneth cell numbers and function in celiac disease (CD), we quantified Paneth cells and human alpha-defensin (HD)-5 and HD-6 in 28 patients with uncomplicated CD, 8 patients with complicated CD (3 with ulcerative jejunoileitis, 2 with refractory sprue, and 3 with enteropathy-associated T-cell lymphoma), and 14 control subjects. Paneth cell numbers and proliferation did not differ in uncomplicated untreated and treated CD and control cases. However, the number of Paneth cells was significantly reduced in complicated CD. Mucosal HD-5 and HD-6 were comparable in uncomplicated untreated and treated CD and control cases. Ex vivo gliadin challenge of treated CD biopsy specimens had no effect on mucosal HD-5 and HD-6 transcripts. Paneth cell numbers and alpha-defensins are unchanged in the mucosa in uncomplicated CD. Further studies are needed to clarify the implications of reduction of numbers of Paneth cells in complicated CD.

Item Type: Article
Uncontrolled Keywords: adult,aged,pathology,cell proliferation,pathology,female,humans,pathology,analysis,male,middle aged,pathology,metabolism,analysis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: LivePure Connector
Date Deposited: 07 Aug 2018 16:30
Last Modified: 08 Aug 2018 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/67969
DOI: 10.1309/5ADNAR4VN11TTKQ6

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