Gut Glucosinolate Metabolism and Isothiocyanate Production

Narbad, Arjan and Trevor Rossiter, John (2018) Gut Glucosinolate Metabolism and Isothiocyanate Production. Molecular Nutrition & Food Research, 62 (18). ISSN 1613-4125

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    The glucosinolate‐myrosinase system in plants has been well studied over the years while relatively little research has been undertaken on the bacterial metabolism of glucosinolates. The products of myrosinase based glucosinolate hydrolysis in the human gut are important to health particularly the isothiocyanates as they are shown to have anticancer properties as well as other beneficial roles in human health. This review is concerned with the bacterial metabolism of glucosinolates but is not restricted to the human gut. Isothiocyanate production and nitrile formation are discussed together with the mechanisms of the formation of these compounds. Side chain modification of the methylsulfinylalkyl glucosinolates is reviewed and the implications for bioactivity of the resultant products is also discussed.

    Item Type: Article
    Additional Information: Special Issue: Isothiocyanates
    Uncontrolled Keywords: glucosinolates,gut bacteria,isothiocyanates,myrosinase,nitriles
    Faculty \ School: Faculty of Science > School of Biological Sciences
    Related URLs:
    Depositing User: LivePure Connector
    Date Deposited: 20 Jun 2018 12:30
    Last Modified: 09 Apr 2019 13:29
    DOI: 10.1002/mnfr.201700991

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