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Abdelhamid, Mahmoud A. S., Fábián, László, MacDonald, Colin J., Cheesman, Myles R., Gates, Andrew J. 
ORCID: https://orcid.org/0000-0002-4594-5038 and Waller, Zoë A. E.
(2018)
Redox-dependent control of i-Motif DNA structure using copper cations.
Nucleic Acids Research, 46 (12).
5886–5893.
ISSN 0305-1048
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Abstract
Previous computational studies have shown that Cu+ can act as a substitute for H+ to support formation of cytosine (C) dimers with similar conformation to the hemi-protonated base pair found in i-motif DNA. Through a range of biophysical methods, we provide experimental evidence to support the hypothesis that Cu+ can mediate C–C base pairing in i-motif DNA and preserve i-motif structure. These effects can be reversed using a metal chelator, or exposure to ambient oxygen in the air that drives oxidation of Cu+ to Cu2+, a comparatively weak ligand. Herein, we present a dynamic and redox-sensitive system for conformational control of an i-motif forming DNA sequence in response to copper cations.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Science Faculty of Science > School of Chemistry Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter Faculty of Science > Research Groups > Chemistry of Light and Energy Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Depositing User: | Pure Connector |
| Date Deposited: | 29 May 2018 10:31 |
| Last Modified: | 27 Jul 2023 07:42 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/67211 |
| DOI: | 10.1093/nar/gky390 |
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