Gold(III) Complexes for Antitumor Applications: An Overview

Bertrand, Benoît, Williams, Morwen RM and Bochmann, Manfred (2018) Gold(III) Complexes for Antitumor Applications: An Overview. Chemistry - A European Journal, 24 (46). pp. 11840-11851. ISSN 0947-6539

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    Abstract

    Gold(III) complexes have emerged as a versatile and effective class of metal‐based anticancer agents. The development of various types of ligands capable of stabilizing the AuIII cation and preventing its reduction under physiological conditions, such as chelating nitrogen‐donors, dithiocarbamates and C^N cyclometalled ligands, has opened the way for the exploration of their potential intracellular targets and action mechanisms. At the same time, the bioconjugation of AuIII complexes has emerged as a promising strategy for improving the selectivity of this class of compounds for cancer cells over healthy tissues, and recent developments have shown that combining gold complexes with molecular structures that are specifically recognized by the cell can exploit the cell's own transport mechanisms to improve selective metal uptake.

    Item Type: Article
    Uncontrolled Keywords: antitumor agents,bioinorganic chemistry,cancer gold,pincer ligands
    Faculty \ School: Faculty of Science > School of Chemistry
    Depositing User: Pure Connector
    Date Deposited: 26 Mar 2018 16:30
    Last Modified: 09 Apr 2019 13:11
    URI: https://ueaeprints.uea.ac.uk/id/eprint/66605
    DOI: 10.1002/chem.201800981

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