Psychotic-like experiences with cannabis use predict cannabis cessation and desire to quit- A cannabis discontinuation hypothesis

Sami, Musa, Notley, Caitlin, Kouimtsidis, Christos, Lynskey, Michael and Bhattacharyya, Sagnik (2019) Psychotic-like experiences with cannabis use predict cannabis cessation and desire to quit- A cannabis discontinuation hypothesis. Psychological Medicine, 49 (1). pp. 103-112. ISSN 0033-2917

[img]
Preview
PDF (Accepted manuscript) - Submitted Version
Download (1358kB) | Preview

    Abstract

    Background: Evidence suggests cannabis-induced psychotic-like experiences may be a marker of psychosis proneness. The effect of such experiences on cannabis use has not systematically been examined. Methods: We undertook a mixed-methods online survey of 1231 cannabis users (including 926 continued users) using the Cannabis Experiences Questionnaire. We examined the effect of psychotic-like and pleasurable experiences on cessation of cannabis and intention to quit. Socio-demographic variables, cannabis use parameters, and substance misuse history were included as covariates. Free-text data explored subjective reasons for changes in use. Results: Cessation of cannabis use was associated with greater psychotic-like experiences (p<0.001, Exp(B) 1.262, 95%CI: 1.179-1.351) whilst continued cannabis users were more likely to report pleasurable experiences(p<0.001, Exp(B) 0.717, 95%CI 0.662-0.776). Intention to quit cannabis in continued users was associated with greater psychotic-like experiences(p<0.003, Exp(B) 1.131, 95%CI: 1.044-1.225) whilst intention to not quit was significantly associated with increased pleasurable experiences (p<0.015,Exp(B) 0.892, 95%CI 0.814-0.978). Whereas former users clearly ascribed cessation to negative experiences; continued users who expressed intention to quit less readily ascribed the intention to negative experiences. Conclusions: Elucidation of psychotic-like experiences may form the basis of a therapeutic intervention for those who wish to quit. Cessation in those with cannabis-induced psychotomimetic experiences may offset the risk for development of psychotic disorder, in this higher risk group.

    Item Type: Article
    Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
    Depositing User: Pure Connector
    Date Deposited: 05 Mar 2018 11:30
    Last Modified: 23 Jan 2019 14:09
    URI: https://ueaeprints.uea.ac.uk/id/eprint/66434
    DOI: 10.1017/S0033291718000569

    Actions (login required)

    View Item