CPMV-DOX Delivers

Aljabali, Alaa A. A., Shukla, Sourabh, Lomonossoff, George P., Steinmetz, Nicole F. and Evans, David J. (2013) CPMV-DOX Delivers. Molecular Pharmaceutics, 10 (1). pp. 3-10. ISSN 1543-8384

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Abstract

The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.

Item Type: Article
Uncontrolled Keywords: cancer,cowpea mosaic virus,doxorubicin,drug delivery,viral nanoparticle
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Chemistry
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Depositing User: Pure Connector
Date Deposited: 10 Nov 2017 06:08
Last Modified: 25 Jul 2018 14:16
URI: https://ueaeprints.uea.ac.uk/id/eprint/65394
DOI: 10.1021/mp3002057

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