Controlling the activities of the diiron centre in bacterial monooxygenases: Lessons from mutagenesis and biodiversity

Nichol, Tim, Murrell, J. Colin and Smith, Thomas J. (2015) Controlling the activities of the diiron centre in bacterial monooxygenases: Lessons from mutagenesis and biodiversity. European Journal of Inorganic Chemistry, 2015 (21). pp. 3419-3431. ISSN 1434-1948

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Abstract

The soluble diiron monooxygenases (SDIMOs) are a diverse group of enzymes that use a diiron active centre to add oxygen to a wide range of organic molecules. Here we review how natural biodiversity and laboratory mutagenesis studies have revealed how the protein scaffold of SDIMOs controls the activity of the enzymes and the presentation of substrates to the diiron site.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Environmental Sciences University of East Anglia Research Groups/Centres > Theme - ClimateUEA
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Environmental Biology
Depositing User:	Pure Connector
Date Deposited:	15 Aug 2017 05:07
Last Modified:	31 Jan 2024 02:16
URI:	https://ueaeprints.uea.ac.uk/id/eprint/64491
DOI:	10.1002/ejic.201500043

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