Markers of left ventricular decompensation in aortic stenosis

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Chin, Calvin WL, Vassiliou, Vassilios ORCID: https://orcid.org/0000-0002-4005-7752, Jenkins, William SA, Prasad, Sanjay K, Newby, David E and Dweck, Marc R (2014) Markers of left ventricular decompensation in aortic stenosis. Expert Review of Cardiovascular Therapy, 12 (7). pp. 901-912. ISSN 1477-9072

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Abstract

Calcified aortic stenosis is a condition that affects the valve and the myocardium. As the valve narrows, left ventricular hypertrophy occurs initially as an adaptive mechanism to maintain cardiac output. Ultimately, the ventricle decompensates and patients transition towards heart failure and adverse events. Current guidelines recommend aortic valve replacement in patients with severe aortic stenosis and evidence of decompensation based on either symptoms or an impaired ejection fraction <50%. However, symptoms can be subjective and correlate only modestly with the severity of aortic stenosis whilst impaired ejection fraction is an advanced manifestation and often irreversible. In this review, the authors will discuss the pathophysiology of left ventricular hypertrophy and the transition to heart failure. Subsequently, the authors will examine novel biomarkers that may better identify the transition from hypertrophy to heart failure and therefore guide the optimal timing for aortic valve replacement.

Item Type: Article
Uncontrolled Keywords: aortic stenosis,cardiac mri,echocardiography,left ventricular decompensation,left ventricular hypertrophy,myocardial fibrosis,myocardial t1 mapping,myocyte death,tissue doppler imaging
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: Pure Connector
Date Deposited: 23 Jun 2017 05:06
Last Modified: 19 Oct 2023 02:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/63817
DOI: 10.1586/14779072.2014.923307

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