Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice

Rusli, Fenni, Lute, Carolien, Boekschoten, Mark V, van Dijk, Miriam, van Norren, Klaske, Menke, Aswin L, Müller, Michael and Steegenga, Wilma T (2017) Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice. Molecular Nutrition & Food Research, 61 (5). ISSN 1613-4125

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      Abstract

      Scope: Calorie restriction (CR) has been shown to extend life- and health-span in model species. For most humans, a life-long CR diet is too arduous to adhere to. The aim of this study was to explore whether weekly intermittent CR can 1) provide long-term beneficial effects and 2) counteract diet-induced obesity in male aging mice. Methods and results: In this study we have exposed C57Bl/6J mice for 24 months to an intermittent (INT) diet, alternating weekly between CR of a control diet and ad libitum moderate-fat (MF) feeding. This weekly intermittent CR significantly counteracted the adverse effects of the MF diet on mortality, body weight and liver health markers in male 24-month-old mice. Hepatic gene expression profiles of INT-exposed animals appeared much more comparable to CR than to MF-exposed mice. At 12 months of age, a subgroup of MF-exposed mice was transferred to the INT diet. Gene expression profiles in the liver of the 24-month-old diet switch mice were highly similar to the INT-exposed mice. However, a small subset of genes was consistently changed by the MF diet during the first phase of life. Conclusion: Weekly intermittent CR largely, but not completely, reversed adverse effects caused by a MF diet.

      Item Type: Article
      Uncontrolled Keywords: aging,intermittent calorie restriction,liver,moderate-fat diet,obesity,transcriptomics
      Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
      University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
      Related URLs:
      Depositing User: Pure Connector
      Date Deposited: 10 Mar 2017 01:40
      Last Modified: 25 Jul 2018 13:01
      URI: https://ueaeprints.uea.ac.uk/id/eprint/62933
      DOI: 10.1002/mnfr.201600677

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