Liquid chromatographic determination of residual isocyanate monomers in plastics intended for food contact use

Damant, A. P., Jickells, Sue M. and Castle, L. (1995) Liquid chromatographic determination of residual isocyanate monomers in plastics intended for food contact use. Journal of AOAC International, 78 (3). pp. 711-719. ISSN 1060-3271

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Abstract

A liquid chromatographic (LC) method was developed for the analysis of 10 isocyanates in polyurethane articles and laminates intended for food use. Residual isocyanates are extracted by dichloromethane with concurrent derivatization by 9-(methylaminomethyl)anthracene. The resultant derivatives are analyzed by reversed-phase LC with fluorescence detection. Separation of the isocyanates was studied and optimized. Quantitation uses 1-naphthyl isocyanate as internal standard and standard addition to the food package. Validation demonstrated the method to have good precision (+/- 2-5%) and recovery (83-95%) for samples spiked with isocyanates at 0.1 mg/kg. The limit of detection was 0.03 mg/kg. Analysis of 19 commercial polyurethane or laminate food packages demonstrated that the method was not prone to interferences. Residues of diphenylmethane-4,4'-diisocyanate were detected in 5 packages and ranged from 0.14 to 1.08 mg/kg.

Item Type: Article
Faculty \ School: Faculty of Science
Faculty of Science > School of Biological Sciences
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Depositing User: Pure Connector
Date Deposited: 01 Mar 2017 01:46
Last Modified: 09 Nov 2018 16:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/62793
DOI:

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