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ToolsQin, Zhiwei, Munnoch, John T, Devine, Rebecca, Holmes, Neil A, Seipke, Ryan F, Wilkinson, Karl A, Wilkinson, Barrie and Hutchings, Matthew I (2017) Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chemical Science, 8 (4). pp. 3218-3227. ISSN 2041-6520
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Abstract
We report a new Streptomyces species named S. formicae that was isolated from the African fungus-growing plant-ant Tetraponera penzigi and show that it produces novel pentacyclic polyketides that are active against MRSA and VRE. The chemical scaffold of these compounds, which we have called the formicamycins, is similar to the fasamycins identified from the heterologous expression of clones isolated from environmental DNA, but has significant differences that allow the scaffold to be decorated with up to four halogen atoms. We report the structures and bioactivities of 16 new molecules and show, using CRISPR/Cas9 genome editing, that biosynthesis of these compounds is encoded by a single type 2 polyketide synthase biosynthetic gene cluster in the S. formicae genome. Our work has identified the first antibiotic from the Tetraponera system and highlights the benefits of exploring unusual ecological niches for new actinomycete strains and novel natural products.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry |
| UEA Research Groups: | Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Organisms and the Environment |
| Depositing User: | Pure Connector |
| Date Deposited: | 11 Feb 2017 02:17 |
| Last Modified: | 12 May 2023 01:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/62428 |
| DOI: | 10.1039/C6SC04265A |
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