The effect of oxidative damage on the calpain proteases in cultured ovine lens

Morton, J.D., Sanderson, J, Lee, H.Y.Y., Robertson, L.J.G. and Gately, K. (2003) The effect of oxidative damage on the calpain proteases in cultured ovine lens. Investigative Ophthalmology and Visual Science, 44 (13). p. 314. ISSN 0146-0404

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Abstract

A line of sheep at Lincoln University inherits cataracts and provides a unique opportunity to investigate the role of calpain in cataract formation. The sheep lens culture system has been developed as an alternative, controlled model of cataract formation allowing the measurement of early changes in cataractogenesis and to test the efficacy of calpain inhibitors in preventing cataracts. The purpose of this experiment was to determine which calpain isoforms were present in the cultured lenses and whether oxidative damage led to changes in the amount and type of calpain isoforms.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Depositing User:	Pure Connector
Date Deposited:	21 Dec 2016 00:02
Last Modified:	08 Mar 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/61791
DOI:

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