The effect of oxidative damage on the calpain proteases in cultured ovine lens

Morton, J.D., Sanderson, J, Lee, H.Y.Y., Robertson, L.J.G. and Gately, K. (2003) The effect of oxidative damage on the calpain proteases in cultured ovine lens. Investigative Ophthalmology and Visual Science, 44 (13). p. 314. ISSN 0146-0404

Full text not available from this repository. (Request a copy)

Abstract

A line of sheep at Lincoln University inherits cataracts and provides a unique opportunity to investigate the role of calpain in cataract formation. The sheep lens culture system has been developed as an alternative, controlled model of cataract formation allowing the measurement of early changes in cataractogenesis and to test the efficacy of calpain inhibitors in preventing cataracts. The purpose of this experiment was to determine which calpain isoforms were present in the cultured lenses and whether oxidative damage led to changes in the amount and type of calpain isoforms.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Pure Connector
Date Deposited: 21 Dec 2016 00:02
Last Modified: 12 Jun 2019 01:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/61791
DOI:

Actions (login required)

View Item