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Veronese, Nicola, Stubbs, Brendon, Solmi, Marco, Smith, Toby O 
ORCID: https://orcid.org/0000-0003-1673-2954, Noale, Marianna, Cooper, Cyrus and Maggi, Stefania
(2017)
Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the Osteoarthritis Initiative.
Age and Ageing, 46 (3).
pp. 470-476.
ISSN 0002-0729
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Abstract
Background: Osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. Objective: To determine whether OA was associated with an increased odds of developing depressive symptoms. Design: Longitudinal cohort study (follow-up: four years). Setting: Data were gathered from the North American Osteoarthritis Initiative (OAI) dataset. Subjects: People at higher risk developing OA. Methods: Osteoarthritis diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after four years. Results: 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (Odds Ratio (OR): 1.26; 95% CI: 0.95-1.67). However, multisite OA (i.e. OA 2>sites; OR: 1.48, 95% CI 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA. Conclusions: This is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | osteoarthritis,depression,depressive symptoms,epidemiology,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation Faculty of Medicine and Health Sciences > Research Groups > Health Promotion Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 26 Oct 2016 12:00 |
| Last Modified: | 19 Oct 2023 01:49 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/61069 |
| DOI: | 10.1093/ageing/afw216 |
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