Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

Bear, Joseph C., Patrick, P. Stephen, Casson, Alfred, Southern, Paul, Lin, Fang-Yu, Powell, Michael J., Pankhurst, Quentin A., Kalber, Tammy, Lythgoe, Mark, Parkin, Ivan P. and Mayes, Andrew G. (2016) Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection. Scientific Reports, 6. ISSN 2045-2322

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    Abstract

    Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.

    Item Type: Article
    Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
    Faculty \ School: Faculty of Science > School of Chemistry
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    Depositing User: Pure Connector
    Date Deposited: 04 Oct 2016 13:03
    Last Modified: 09 Apr 2019 11:35
    URI: https://ueaeprints.uea.ac.uk/id/eprint/60729
    DOI: 10.1038/srep34271

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