Effects of vitamin D supplementation on endothelial function:a systematic review and meta-analysis of randomised clinical trials

Hussin, Azizah Mat, Ashor, Ammar W, Schoenmakers, Inez, Hill, Tom, Mathers, John C and Siervo, Mario (2017) Effects of vitamin D supplementation on endothelial function:a systematic review and meta-analysis of randomised clinical trials. European Journal of Nutrition, 56 (3). 1095–1104. ISSN 1436-6207

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    Abstract

    Background: In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling. This systematic review and meta-analysis of randomised clinical trials (RCTs) were conducted to investigate the effect of vitamin D supplementation on EF and to examine whether the effect size was modified by health status, study duration, dose, route of vitamin D administration, vitamin D status (baseline and post-intervention), body mass index (BMI), age and type of vitamin D. Methods: We searched the Medline, Embase, Cochrane Library and Scopus databases from inception until March 2015 for studies meeting the following criteria: (1) RCT with adult participants, (2) vitamin D administration alone, (3) studies that quantified EF using commonly applied methods including ultrasound, plethysmography, applanation tonometry and laser Doppler. Results: Sixteen articles reporting data for 1177 participants were included. Study duration ranged from 4 to 52 weeks. The effect of vitamin D on EF was not significant (SMD: 0.08, 95 % CI −0.06, 0.22, p = 0.28). Subgroup analysis showed a significant improvement of EF in diabetic subjects (SMD: 0.31, 95 % CI 0.05, 0.57, p = 0.02). A non-significant trend was found for diastolic blood pressure (β = 0.02; p = 0.07) and BMI (β = 0.05; p = 0.06). Conclusions: Vitamin D supplementation did not improve EF. The significant effect of vitamin D in diabetics and a tendency for an association with BMI may indicate a role of excess adiposity and insulin resistance in modulating the effects of vitamin D on vascular function. This remains to be tested in future studies.

    Item Type: Article
    Uncontrolled Keywords: vitamin d,nitric oxide,flow-mediated dilation,forearm blood flow,pulse wave velocity,cardiovascular risk
    Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
    Depositing User: Pure Connector
    Date Deposited: 29 Sep 2016 13:00
    Last Modified: 21 Mar 2019 11:32
    URI: https://ueaeprints.uea.ac.uk/id/eprint/60630
    DOI: 10.1007/s00394-016-1159-3

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