Disruption of dorsolateral prefrontal cortex decreases model-based in favor of model-free control in humans

Smittenaar, Peter, FitzGerald, Thomas H B, Romei, Vincenzo, Wright, Nicholas D and Dolan, Raymond J (2013) Disruption of dorsolateral prefrontal cortex decreases model-based in favor of model-free control in humans. Neuron, 80 (4). pp. 914-919. ISSN 0896-6273

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Abstract

Human choice behavior often reflects a competition between inflexible computationally efficient control on the one hand and a slower more flexible system of control on the other. This distinction is well captured by model-free and model-based reinforcement learning algorithms. Here, studying human subjects, we show it is possible to shift the balance of control between these systems by disruption of right dorsolateral prefrontal cortex, such that participants manifest a dominance of the less optimal model-free control. In contrast, disruption of left dorsolateral prefrontal cortex impaired model-based performance only in those participants with low working memory capacity.

Item Type: Article
Additional Information: Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Uncontrolled Keywords: adolescent,adult,behavior,choice behavior,female,functional laterality,humans,male,memory, short-term,models, neurological,prefrontal cortex,psychomotor performance,theta rhythm,transcranial magnetic stimulation,young adult
Faculty \ School: Faculty of Social Sciences > School of Psychology
Depositing User: Pure Connector
Date Deposited: 14 Apr 2016 11:01
Last Modified: 11 Apr 2019 15:47
URI: https://ueaeprints.uea.ac.uk/id/eprint/58237
DOI: 10.1016/j.neuron.2013.08.009

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