The malignancy grading method is not a reliable assessment of malignancy in mesothelioma

Tierney, G, Wilkinson, M J and Jones, J S (1990) The malignancy grading method is not a reliable assessment of malignancy in mesothelioma. The Journal of Pathology, 160 (3). pp. 209-11. ISSN 0022-3417

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Abstract

The ploidy of a series of pleural lesions--reactive proliferations, malignant mesotheliomas and metastatic tumours--was measured on a Leitz Miamed DNA image analyser using Feulgen-stained slides. The technique successfully recognized all the metastatic tumours as malignant; this corresponds to previous work. However, it was not successful in classifying mesothelial lesions as benign or malignant, resulting in a very high false-negative rate and a moderately high false-positive rate. Mesothelial lesions appear to have a wide range of ploidy values irrespective of their biological behaviour. Thus, for primary mesothelial tumours, the ploidy value cannot be used as a reliable diagnostic index.

Item Type: Article
Uncontrolled Keywords: false negative reactions,false positive reactions,humans,mesothelioma,pleural neoplasms,ploidies
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 23 Mar 2016 13:01
Last Modified: 27 Jul 2018 15:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/57994
DOI: 10.1002/path.1711600305

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