Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis

Beales, Ian, Dearman, Leanne, Vardi, Inna and Loke, Yoon (2016) Reduced risk of Barrett’s esophagus in statin users: case–control study and meta-analysis. Digestive Diseases and Sciences, 61 (1). pp. 238-246. ISSN 0163-2116

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    Abstract

    Background: Use of statins has been associated with a reduced incidence of esophageal adenocarcinoma in population-based studies. However there are few studies examining statin use and the development of Barrett’s esophagus. Aim: The purpose of this study was to examine the association between statin use and the presence of Barrett’s esophagus in patients having their first gastroscopy. Methods: We have performed a case–control study comparing statin use between patients with, and without, an incident diagnosis of non-dysplastic Barrett’s esophagus. Male Barrett’s cases (134) were compared to 268 male age-matched controls in each of two control groups (erosive gastro-esophageal reflux and dyspepsia without significant upper gastrointestinal disease). Risk factor and drug exposure were established using standardised interviews. Logistic regression was used to compare statin exposure and correct for confounding factors. We performed a meta-analysis pooling our results with three other case–control studies. Results: Regular statin use was associated with a significantly lower incidence of Barrett’s esophagus compared to the combined control groups [adjusted OR 0.62 (95 % confidence intervals 0.37–0.93)]. This effect was more marked in combined statin plus aspirin users [adjusted OR 0.43 (95 % CI 0.21–0.89)]. The inverse association between statin or statin plus aspirin use and risk of Barrett’s was significantly greater with longer duration of use. Meta-analysis of pooled data (1098 Barrett’s, 2085 controls) showed that statin use was significantly associated with a reduced risk of Barrett’s esophagus [pooled adjusted OR 0.63 (95 % CI 0.51–0.77)]. Conclusions: Statin use is associated with a reduced incidence of a new diagnosis of Barrett’s esophagus.

    Item Type: Article
    Uncontrolled Keywords: barrett’s esophagus,statins,aspirin,esophageal cancer
    Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
    Depositing User: Pure Connector
    Date Deposited: 17 Mar 2016 00:05
    Last Modified: 23 Jan 2019 13:59
    URI: https://ueaeprints.uea.ac.uk/id/eprint/57504
    DOI: 10.1007/s10620-015-3869-4

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