Targeting of plant pattern recognition receptor-triggered immunity by bacterial type-III secretion system effectors

Macho, Alberto P and Zipfel, Cyril (2015) Targeting of plant pattern recognition receptor-triggered immunity by bacterial type-III secretion system effectors. Current Opinion in Microbiology, 23. pp. 14-22. ISSN 1369-5274

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Abstract

During infection, microbes are detected by surface-localized pattern recognition receptors (PRRs), leading to an innate immune response that prevents microbial ingress. Therefore, successful pathogens must evade or inhibit PRR-triggered immunity to cause disease. In the past decade, a number of type-III secretion system effector (T3Es) proteins from plant pathogenic bacteria have been shown to suppress this layer of innate immunity. More recently, the detailed mechanisms of action have been defined for several of these effectors. Interestingly, effectors display a wide array of virulence targets, being able to prevent activation of immune receptors and to hijack immune signaling pathways. Besides being a fascinating example of pathogen-host co-evolution, effectors have also emerged as valuable tools to dissect important biological processes in host cells.

Item Type:	Article
Uncontrolled Keywords:	bacteria,bacterial secretion systems,host-pathogen interactions,immune evasion,plants,pattern recognition receptors,virulence factors
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	Pure Connector
Date Deposited:	09 Mar 2016 16:01
Last Modified:	21 Oct 2022 04:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/57403
DOI:	10.1016/j.mib.2014.10.009

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