IFCC standardised HbA(1c): should the world be as one?

John, Garry and English, Emma (2012) IFCC standardised HbA(1c): should the world be as one? Clinical Chemistry and Laboratory Medicine, 50 (7). pp. 1243-1248. ISSN 1434-6621

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Abstract

The central importance of HbA(1c) in monitoring glycaemic control was highlighted by the Diabetes Control and Complications Trial (DCCT) which showed that improved glycaemic control, as monitored by HbA(1c), delayed the onset of diabetic complications. Following this publication the issue of international standardisation of glycated haemoglobin (GHb) measurements became an important objective. The lack of international standardisation resulted in several countries developing National Standardisation Programmes. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group on HbA(1c) Standardisation has established a reference measurement procedure (HPLC-MS or HPLC-CE) for HbA(1c) embracing the concept of metrological traceability. The reference method is anchored to a global network of 15 approved reference laboratories; this confers sustainability and a low level of uncertainty. Essential elements of a comprehensive reference measurement system additionally include the definition of the measurand and the unit of measurement. HbA(1c) is defined as haemoglobin (Hb) molecules having a stable adduct of glucose to the N-terminal valine of the β chain [Hb β chain (Blood) - N-(1-deoxyfructos-1-yl) Hb β chain] and that mmol/mol be used as the unit of measurement. These developments will result in improvements in inter-method and inter-laboratory agreement. Additionally, global acceptance of standardisation based on metrologically sound principles will enable clinical goals and diagnostic guidelines to be developed that can be adopted by all countries.

Item Type: Article
Uncontrolled Keywords: chemistry, clinical,clinical laboratory techniques,diabetes complications,diabetes mellitus,hemoglobin a, glycosylated,humans,international cooperation,reference standards
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 27 Jan 2016 15:00
Last Modified: 25 Jul 2018 11:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/56801
DOI: 10.1515/cclm-2011-0853

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