Functional coupling of the amygdala in depressed patients treated with antidepressant medication

Chen, Chi-Hua, Suckling, John, Ooi, Cinly, Fu, Cynthia H Y, Williams, Steve C R, Walsh, Nicholas D, Mitterschiffthaler, Martina T, Pich, Emilio Merlo and Bullmore, Ed (2008) Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology, 33 (8). pp. 1909-1918. ISSN 0893-133X

Full text not available from this repository. (Request a copy)

Abstract

The amygdala plays a central role in various aspects of affect processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems. We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic resonance imaging data acquired from 19 patients with major depressive disorder and 19 healthy volunteers, each scanned twice (at baseline and 8 weeks later) during performance of an implicit facial affect processing task. Between scanning sessions, the patients received treatment with an antidepressant drug, fluoxetine 20 mg/day. We found that the amygdala was positively coupled bilaterally with medial temporal and ventral occipital regions, and negatively coupled with the anterior cingulate cortex. Antidepressant treatment was associated with significantly increased coupling between the amygdala and right frontal and cingulate cortex, striatum, and thalamus. Treatment-related increases in functional coupling to frontal and other regions were greater for the left amygdala than for the right amygdala. These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico-limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala.

Item Type: Article
Uncontrolled Keywords: adult,amygdala,analysis of variance,antidepressive agents, second-generation,brain mapping,depressive disorder, major,facial expression,female,fluoxetine,functional laterality,humans,image processing, computer-assisted,magnetic resonance imaging,male,middle aged,psychiatric status rating scales,social perception
Faculty \ School: Faculty of Social Sciences > School of Psychology
University of East Anglia > Faculty of Social Sciences > Research Groups > Social and Developmental Psychology
Depositing User: Pure Connector
Date Deposited: 19 Nov 2015 08:22
Last Modified: 03 Sep 2018 10:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/55459
DOI: 10.1038/sj.npp.1301593

Actions (login required)

View Item