Segmentation analysis in functional MRI: activation sensitivity and gray-matter specificity of RARE and FLASH

Hutchinson, M., Rusinek, H., Nenov, V. I., Feinberg, D. A. and Johnson, G. (1997) Segmentation analysis in functional MRI: activation sensitivity and gray-matter specificity of RARE and FLASH. Journal of Magnetic Resonance Imaging, 7 (2). pp. 361-364. ISSN 1053-1807

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Abstract

Brain activation is accompanied by local decreases in vascular deoxyhemoglobin. Theoretically, gradient-echo and spin-echo sequences show similar sensitivity to capillary deoxyhemoglobin, but spin-echo sequences should be less sensitive to venous deoxyhemoglobin. This is an important distinction in the context of cortical localization. We report herein a direct experimental comparison of a gradient-echo sequence (fast low-angle shot [FLASH]) with a spin-echo sequence (rapid acquisition with relaxation enhancement [RARE]) for functional MRI (fMRI) in seven subjects undergoing visual stimulation. A Student t test analysis was used to locate areas of significant activation, and then computerized image segmentation was performed to determine the type of activated tissue. Contrary to previous reports, both sequences proved equally sensitive to overall activation. RARE activation, however, was more specific for gray matter, as suggested by prior theoretical models.

Item Type:	Article
Uncontrolled Keywords:	functional mri,segmentation analysis,sensitivity,specificity
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	05 Oct 2015 14:49
Last Modified:	21 Oct 2022 01:17
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54545
DOI:	10.1002/jmri.1880070217

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