Vasorelaxant activity of essential oils from Croton zambesicus and some of their constituents.

Baccelli, Chiara, Martinsen, Anneloes, Morel, Nicole and Quetin-Leclercq, Joelle (2010) Vasorelaxant activity of essential oils from Croton zambesicus and some of their constituents. Planta Medica, 76 (14). pp. 1506-1511. ISSN 0032-0943

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Abstract

In this study, we determined the vasorelaxant activity of essential oils of different samples of CROTON ZAMBESICUS collected in the same area in Benin at different periods and analysed their compositions by GC-FID and GC-MS. 68 compounds were identified among which 20 have not been described previously in this plant's essential oils. We observed quantitative differences among essential oils but all possess significant vasorelaxant activity on intact rat aortae contracted by KCl (IC (50) 5.6-11.8 µg/mL). This activity may, at least in part, be explained by the presence of vasorelaxant diterpenes such as ENT-18-hydroxy-trachyloban-3-one, isopimara-7,15-dien-3β-ol, and ENT-18-hydroxy-isopimar-7,15-dien-3β-ol, previously isolated from the dichloromethane extract of the leaves, but also to linalool (IC (50) 43.4 µg/mL) and particularly to caryophyllene oxide (IC (50) 2.5 µg/mL).

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/20422...
Depositing User:	Pure Connector
Date Deposited:	18 Sep 2015 14:36
Last Modified:	03 Jan 2023 17:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54351
DOI:	10.1055/s-0030-1249820

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