The association of age with gastric emptying

Gainsborough, N, Maskrey, V L, Nelson, M L, Keating, J, Sherwood, R A, Jackson, S H and Swift, C G (1993) The association of age with gastric emptying. Age and Ageing, 22 (1). pp. 37-40. ISSN 0002-0729

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Abstract

Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.

Item Type: Article
Uncontrolled Keywords: acetaminophen,adult,aged,aged 80 and over,aging,female,gastric emptying,half-life,humans,intestinal absorption,male,middle aged,pilot projects,reference values
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 30 Apr 2015 13:26
Last Modified: 21 Aug 2018 11:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/53209
DOI: 10.1093/ageing/22.1.37

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