Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

Anderson, R A, Evans, L M, Ellis, G R, Khan, N, Morris, K, Jackson, S K, Rees, A, Lewis, M J and Frenneaux, M P (2006) Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes. Diabetic Medicine, 23 (3). pp. 258-64. ISSN 0742-3071

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Abstract

Endothelial dysfunction (ED) has been described in Type 2 diabetes (T2DM). We have described previously a diminution of flow-mediated arterial dilatation and, by implication, further ED in T2DM in response to postprandial lipaemia (PPL) at 4 h. This is possibly mediated by oxidative stress/alteration of the nitric oxide (NO) pathway. T2DM subjects tend to exhibit both exaggerated and prolonged PPL. We therefore studied the relationship of PPL to the duration of ED in T2DM subjects and oxidative stress with or without the antioxidant, vitamin C.

Item Type: Article
Uncontrolled Keywords: administration, oral,adult,aged,antioxidants,area under curve,ascorbic acid,cholesterol, hdl,cholesterol, ldl,diabetes mellitus, type 2,dietary fats,endothelium,female,humans,lipid peroxidation,lipids,lipoproteins, vldl,male,middle aged,oxidative stress,postprandial period,triglycerides,vasodilation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 13 Mar 2015 16:50
Last Modified: 19 Nov 2018 16:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/52665
DOI: 10.1111/j.1464-5491.2005.01767.x

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