Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease:A Review of the Literature

Martin, Thomas D, Chan, Simon S M and Hart, Andrew R (2015) Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease:A Review of the Literature. Digestive Diseases and Sciences, 60 (5). pp. 1396-1405. ISSN 0163-2116

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Abstract

The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics), lifestyle factors (smoking, psychological stress, diet and air pollution) may precipitate clinical relapses and recurrence. Potential biological mechanisms include: increasing thrombotic tendency, imbalances in prostaglandin synthesis, alterations in the composition of gut microbiota, and mucosal damage causing increased permeability.

Item Type: Article
Uncontrolled Keywords: relapse,recurrence,inflammatory bowel disease,precipitating factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Feb 2015 12:36
Last Modified: 23 Jan 2019 13:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/52174
DOI: 10.1007/s10620-014-3437-3

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