Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Jakszyn, Paula, Bingham, Sheila, Pera, Guillem, Agudo, Antonio, Luben, Robert, Welch, Ailsa, Boeing, Heiner, Del Giudice, Giuseppe, Palli, Domenico, Saieva, Calogero, Krogh, Vittorio, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Hallmans, Göran, Sanchez, María José, Larrañaga, Nerea, Barricarte, Aurelio, Chirlaque, María Dolores, Quirós, José R, Key, Timothy J, Allen, Naomi, Lund, Eiliv, Carneiro, Fátima, Linseisen, Jakob, Nagel, Gabriele, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Bueno-de-Mesquita, H Bas, Ocké, Marga O, Peeters, Petra Hm, Numans, Mattijs E, Clavel-Chapelon, Françoise, Trichopoulou, Antonia, Fenger, Claus, Stenling, Roger, Ferrari, Pietro, Jenab, Mazda, Norat, Teresa, Riboli, Elio and Gonzalez, Carlos A (2006) Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis, 27 (7). pp. 1497-1501. ISSN 0143-3334

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Abstract

The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

Item Type: Article
Uncontrolled Keywords: adenocarcinoma,animals,ascorbic acid,case-control studies,cattle,diet,dimethylnitrosamine,europe,female,helicobacter infections,helicobacter pylori,humans,iron,male,meat,middle aged,nitrosamines,prospective studies,risk factors,stomach neoplasms
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Feb 2015 13:22
Last Modified: 21 Mar 2019 11:14
URI: https://ueaeprints.uea.ac.uk/id/eprint/52142
DOI: 10.1093/carcin/bgl019

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