Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

Malavaud, Bernard, Pchejetski, Dmitry, Mazerolles, Catherine, de Paiva, Geisilène Russano, Calvet, Cyril, Doumerc, Nicolas, Pitson, Stuart, Rischmann, Pascal and Cuvillier, Olivier (2010) Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens. European Journal of Cancer, 46 (18). pp. 3417-24. ISSN 1879-0852

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Abstract

Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.

Item Type: Article
Additional Information: Copyright © 2010 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords: aged,humans,immunohistochemistry,male,microarray analysis,middle aged,neoplasm proteins,phosphotransferases (alcohol group acceptor),prostatic neoplasms
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 16 Dec 2014 10:06
Last Modified: 25 Jul 2018 10:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/51533
DOI: 10.1016/j.ejca.2010.07.053

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