On the Use of pH titration to quantitatively characterize colloidal nanoparticles

Charron, Gaelle, Pickett, Christopher and Nann, Thomas (2012) On the Use of pH titration to quantitatively characterize colloidal nanoparticles. Langmuir, 28 (43). pp. 15141-15149. ISSN 0743-7463

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Abstract

Functional nanoparticles (NPs) for bioapplications have been achieved, thanks to synthesis providing high quality nanocrystals, efficient procedures for transfer in water, and further conjugation of (bio)active molecules. However, these nanomaterials are still subjected to batch-to-batch variability and investigations of their physicochemical properties and chemical reactivity are still in their infancy. This may be due to lack of a routine, cost-effective, and readily available quantitative method for characterizing functional NPs. In this work, we show that pH titrations can be a powerful tool for investigating the surface properties of charged NPs and quantifying their surface functionalities. We demonstrate how this method can be useful in characterizing the colloidal and chemical stability, composition, and purity of the nanomaterial. The method also shows potential for the optimization of conjugation conditions.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User:	Pure Connector
Date Deposited:	10 Nov 2014 16:08
Last Modified:	25 Sep 2024 11:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/50635
DOI:	10.1021/la302570s

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