Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling

Moreno, Estefanía, Andradas, Clara, Medrano, Mireia, Caffarel, María M., Perez-Gomez, Eduardo, Blasco-Benito, Sandra, Gomez-Canas, Maria, Pazos, M. Ruth, Irving, Andrew J., Lluis, Carme, Canela, Enric I., Fernandez-Ruiz, Javier, Guzmán, Manuel, McCormick, P. J. and Sanchez, Cristina (2014) Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. The Journal of Biological Chemistry, 289 (32). pp. 21960-21972. ISSN 1083-351X

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Abstract

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.

Item Type:	Article
Uncontrolled Keywords:	cancer,cannabinoid,cannabinoid receptor ,g protein-coupled receptor (gpcr) ,signal transduction ,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.jbc.org/content/289/32/21960....
Depositing User:	Pure Connector
Date Deposited:	26 Aug 2014 14:52
Last Modified:	04 Jul 2023 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49978
DOI:	10.1074/jbc.M114.561761

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