Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease

Pavlidis, Polychronis, Romanidou, Ourania, Roggenbuck, Dirk, Mytilinaiou, Maria G, Al-Sulttan, Faris, Liaskos, Christos, Smyk, Daniel S, Koutsoumpas, Andreas L, Rigopoulou, Eirini I, Conrad, Karsten, Forbes, Alastair and Bogdanos, Dimitrios P (2012) Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease. Clinical & Developmental Immunology, 2012. p. 640835. ISSN 1740-2530

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Abstract

Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 is also present on the apical surface of microfold (M) intestinal cells. As the colon lacks GP2-rich M cells, we assumed that patients with colonic CD are seronegative for anti-GP2. Anti-GP2 antibodies were tested in 225 CDs, including 45 patients with colonic location (L2), 45 with terminal ileum (L1) and 135 with ileocolonic involvement; 225 patients with ulcerative colitis (UC) were also tested. Anti-GP2 reactivity was detected in 59 (26.2%) CDs and 15 (6.7%) UCs (P

Item Type: Article
Uncontrolled Keywords: adult,autoantibodies,autoantigens,colitis, ulcerative,crohn disease,female,gpi-linked proteins,humans,ileitis,immunoglobulin g,inflammation,inflammatory bowel diseases,male,membrane glycoproteins,middle aged,pancreas
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:52
Last Modified: 29 Aug 2018 10:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/49832
DOI: 10.1155/2012/640835

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