Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

, Wellcome Trust Case Control Consortium and Forbes, Alastair (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447 (7145). pp. 661-78. ISSN 0028-0836

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Abstract

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P

Item Type: Article
Uncontrolled Keywords: arthritis, rheumatoid,bipolar disorder,case-control studies,chromosomes, human,coronary artery disease,crohn disease,diabetes mellitus,gene frequency,genetic markers,genetic predisposition to disease,genetics, population,genome, human,geography,great britain,humans,hypertension
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:36
Last Modified: 25 Jul 2018 09:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/49825
DOI: 10.1038/nature05911

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